Metabolism & Pharmacokinetics

pharmacokineticsAvogadro LS can provide our human and veterinary pharmaceutical clients a range of services related to metabolism and pharmacokinetic studies.  Avogadro LS offers in vivo studies in laboratory and veterinary species, which include early PK, supporting screening of formulations, pre-clinical pharmacokinetics and ADME (Absorption, Distribution, Metabolism, Excretion).

Avogadro LS can also support bioequivalence, safety (residues, tolerance…), and efficacy (pharmacologically-induced models, challenge tests…) studies performed on target animal species.

Techniques :
Jugular catheterization, repeat sampling, microsampling in rodents
Bile duct cannulation in rats, mice and dogs
Surgical models can be performed on request

Development Services

Human Drug Development Services

Avogadro LS can perform various studies to faciliate human drug development, including but not limited to:

    • Pharmacokinetic
    • Bioavailability
    • Drug-drug interaction
    • PK/PD
    • Early pharmacokinetic
    • Mass balance excretion
    • Drug distribution with radiolabeled or non radiolabeled entities
    • Performance of studies in a variety of laboratory animal species

Veterinary Drug Development Services

Avogadro LS can facilitate development of veterinary drugs and biologics by offering the following services:

    • Pharmacokinetic
    • Bioavailability
    • Bioequivalence
    • Drug-drug interaction
    • PK/PD
    • Early pharmacokinetic
    • Mass balance excretion
    • Drug distribution with radiolabeled or non radiolabeled entities
    • Performance of studies in companion and food producing species